Folate therapy optimization in complicated pregnancy

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Folate requirement in pregnancy.

economic strata and are often residents of rural areas. Diet lacks high-class proteins and consists mostly of cereals and a small quantity of pulses. Very low levels of total serum proteins and albumin are noted in hospitalized patients. The presumptive evidence of protein malnutrition and deprivation is strong, unlike the cryptogenic types in Britain. Less than a quarter of patients give a his...

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Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect.

BACKGROUND In the absence of clinical folate deficiency, periconceptional supplementation with folic acid reduces a woman's risk of having an infant with a neural-tube defect. Since antiserum to folate receptors induces embryo resorption and malformations in rats, we hypothesized that autoantibodies against folate receptors in women may be associated with pregnancy complicated by a neural-tube ...

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The importance of folate during pregnancy was addressed 40 years ago by Bryan Hibbard (1 ) in his study of folate status in 1484 low-income obstetric patients from Liverpool. He assessed folate status as urinary excretion of formiminoglutamic acid. Abnormal formiminoglutamic acid excretion was related not only to placental abruption and spontaneous abortion but also to adverse outcomes in previ...

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Complicated Choledochal Cysts in Pregnancy

Choledochal cyst is congenital dilatation of the biliary tract, present primarily in infants. This condition in pregnancy is very rare, and the clinical manifestations are nonspecific and variable. In late pregnancy, the symptoms may exacerbate due to hormonal effects and the compression of the common bile duct by the enlarging uterus. The need for urgent therapy of the complications associated...

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Optimization of folate-conjugated liposomal vectors for folate receptor-mediated gene therapy.

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ژورنال

عنوان ژورنال: Journal of obstetrics and women's diseases

سال: 2013

ISSN: 1683-9366,1684-0461

DOI: 10.17816/jowd62625-36